Spines and Computational Modeling

Finite element models can provide predictions of stress and strain distributions in complex, fiber-reinforced tissues, which may be difficult or impossible to measure experimentally. Additionally, the models can also be used to guide experimental designs for studies that are time- or cost-intensive.

Our group has developed both tissue- and joint-level finite element models. The multiscale, structure-based tissue-level model is rigorously validated under multiple loading modalities, loading conditions, and boundary conditions, allowing us to simultaneously investigate both tissue- and subtissue-level mechanics. The model also has the potential to directly evaluate fiber-matrix interactions. The joint-level model is validated under multiple loading modalities and enables us to assess the effect of degeneration and combined multiaxial loading on disc mechanics.

The current work is centered on adolescent idiopathic scoliosis (AIS) and improving our understanding of pre-operative and surgical treatment techniques for adolescent patients with AIS. In collaboration with Phoenix Children’s Hospital, the University of Arizona, Phoenix, and the University of Wisconsin-Madison, we seek to investigate the mechanical, biochemical, and physiological mechanisms that underpin the development of scoliosis and engineer clinical and public health driven treatment techniques through the use of medical imaging and finite element modeling.