Journal Articles
2023/In Press
61. Zhou M, Theologis AA, O’Connell GD. Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research. JOR Spine – In Press, 09, 2023.
60. Zhou M*, Archibeck ES*, Feteih Y, Abubakr Y, O’Connell, G.D., Gu, G.X. Non-enzymatic glycation increases the failure risk of annulus fibrosus by predisposing the extrafibrillar matrix to greater stresses. Acta Biomaterialia S1742-7061(23), July 2023. *These authors contributed to this work equally.
2022
59. Abed MR, Archibeck ES, Isied RS, Feteih Y, O’Connell GD, Gu GX. Influence of Radial Stiffness Gradient on Porous Composite Bulk Mechanics. Advanced Engineering Materials, p.2201681.
58. McKinley JP, Montes AR, Wang MN, Kamath AR, Jimenez G, Lim J, Marathe SA, Mofrad MRK, O’Connell GD. Design of a flexing organ-chip to model in situ loading of the intervertebral disc. Biomicrofluidics, 16(5).
57. Lim S, Huff, RD, Veres JE, Satish D, O’Connell GD. Disc geometry measurement methods affect reported compressive mechanics by up to 65%. JOR Spine, issue e1214.
56. López-Marcial GR, Elango K, O’Connell GD. Addition of collagen type I in agarose created a dose-dependent effect on matrix production in engineered cartilage. Regenerative Biomaterials, 9, p.rbac048.
55. Zhou M, Huff RD, Abubakr Y, O’Connell GD. Torque- and muscle-driven flexion induced disparate risk of in vitro herniation: A multiscale and multiphasic structure-based finite element study. J Biomech Eng. Jun 2022, 144(6): 061005
54. Yan Y, Fan H, Li Y, Hoeglinger E, Wiesinger A, Barr A, O’Connell GD, Harris-Adamson C. Applying wearable technology and a deep learning model to predict occupational physical activities. Applied Sciences. Applied Sciences, 11(20), p.9636.
53. Werbner B, McMindes N, Zhou M, Lee A, Lee M, O’Connell GD. Saline-polyethylene glycol blends preserve annulus fibrosus hydration and mechanics: an experimental and finite element analysis. JMBBM, 125:104951, Jan. 2022.
2021
52. Werbner B, Lee M, Lee A, Yang L, Habib A, Fields AJ, O’Connell GD. Non-enzymatic glycation of annulus fibrosus alters tissue-level failure mechanics in tension. JMBBM, 126:104992, Nov. 2021.
51. Pendleton MM, Emerzian SR, Sadoughi S, Li A, Liu J, Tang SY, O’Connell GD, Sibonga JD, Alwood JS, Keaveny TM. Relations between bone quality, microarchitecture, and collagen-crosslinks on mechanics following in vivo irradiation in mice. J Bone Mineral Research, Vol. 5(11), e10545, Nov. 2021.
50. Yang B, Klineberg E, O’Connell GD. Intervertebral Disc Mechanics with Nucleotomy: Differences between simple and complex loading. J of Biomech Eng., Aug 1;143(8):081002, Aug. 2021.
49. Zhou M, Lim S, O’Connell GD. A Robust Multiscale and multiphasic structure-based modeling framework for the intervertebral disc. Frontiers, 7;9:685799, June 2021.
48. Zhou M, Werbner B, O’Connell GD. Fiber engagement accounts for geometry-dependent annulus fibrosus mechanics: A Multiscale, Structure-Based Finite Element Study. Invited paper for Special Issue: “Cell and Tissue Biomechanics: A Correlation of Structure and Function” to JMBBM, 115:104292, Mar. 2021.
47. Costi JC*, Ledet E*, O’Connell GD*. Spine Biomechanical Testing Methodologies: The Controversy of Consensus vs Scientific Evidence. JOR Spine, Vol. 4(1), Mar. 2021. *Indicates co-corresponding authors.
2020
46. Bezci SE, Torres K, Carraro C, Chiavacci D, Werbner B, Lim S, O’Connell GD. Transient swelling behavior of the bovine caudal disc. JMBBM, Vol. 112, 104089, Dec. 2020.
45. Newell N*, Tapia RED, Lim S, Rahman T, O’Connell GD*, Holsgrove TP*. Influence of testing environment and loading rate on intervertebral disc compressive mechanics: An assessment of repeatability at three different laboratories. JOR Spine – In Press for Special Issue: Protocols, Methods, and Resources for Spine Research, 06/2020. *Indicates co-corresponding authors.
44. Bezci SE, Lin S, O’Connell GD. Nonlinear stress-dependent recovery behavior of the intervertebral disc. JMBBM, Vol 110: 103881, Oct. 2020.
43. Yang B, Wendland M, O’Connell GD. Direct water content measurements using quantitative magnetic resonance imaging. JMRI – In Press, Apr., 2020.
42. Zhou M, Bezci SE, O’Connell GD. Multiscale composite model of fiber-reinforced tissues with direct representation of subtissue properties. BMMB, Vol 19(2): 745-759, Apr. 2020.
41. Zhou M*, Werbner B*, O’Connell GD. Historical review on combined experimental and computational approaches for investigating annulus fibrosus mechanics. *These authors contributed equally to the work. Special Article for ASME YC Fung Awardee; J of Biomech. Eng, 142(3), Mar 2020.
2019
40. Yang B, O’Connell GD. Intervertebral disc swelling maintains strain homeostasis throughout the annulus fibrosus: A finite element analysis of healthy and degenerated discs. Acta Biomaterialia Vol. 100, 61-74, Dec. 2019.
39. Soepriantna AH, Yeh AK, Clifford AD, Bezci SE, O’Connell GD, Goergen CJ. 3D Myocardial Strain Correlates with Murine Left Ventricular Remodeling Severity Post-Infarction. Journal of the Royal Society 16(160):20190570, Nov., 2019.
38. Pendleton MM*, Emerzian S*, Liu J, Tang SY, O’Connell GD, Alwood JS, Keaveny TM. Effects of ex vivo Ionizing Radiation on Collagen Structure and Whole-Bone Mechanical Properties of Mouse Vertebrae. *These authors contributed equally to the work. Bone Vol. 128, 115043, Nov., 2019.
37. Eskandari M, Nordgren TM, O’Connell GD. Mechanics of Pulmonary Airways: Linking Structure to Function Through Constitutive Modeling, Biochemistry, and Histology. Acta Biomateriala 97(1): 512-523, Oct. 2019.
36. Bezci SE, Werbner B, Zhou M, Malollari K, Carraro C, O’Connell GD. Radial variation in biochemical composition of the bovine caudal intervertebral disc. JOR Spine; 2(3), e1065, Sept. 2019.
35. Yang B, Lu Y, Um C, O’Connell GD. Relative Nucleus Pulposus Area and Position Alters Disc Joint Mechanics. J Biomech Eng. 141(5): 051004, 2019.
34. Yang B, O’Connell GD. GAG content, fiber stiffness, and fiber angle affect swelling-based residual stress in the intact annulus fibrosus. BMMB 18(3): 617-630, 2019.
33. Werbner B, Spack K, O’Connell GD. Bovine Annulus Fibrosus Hydration Affects Rate-Dependent Failure Mechanics Under Monotonic Tension. J Biomech. Jan; 89: 34-39, 2019.
2018
32. Pendleton MM, Sadoughi S, Li A, O’Connell GD, Alwood JS, Keaveny TM. High-Precision Method for Cyclic Loading of Small Animal Vertebrae to Assess Bone Quality. Bone Reports 9(12): 165-172, 2018.
31. López-Marcial GR, Zeng AY, Osuna C, García JM*, O’Connell GD*. Characterization of Printable Bioinks for Cartilage Tissue Engineering. * co-corresponding authors. ACS Biomaterials 4(10):3610-3616, 2018.
30. Bezci SE, Eleswarapu A, Klineberg EO, O’Connell GD. Contribution of facets, axial compression, and composition on human lumbar discs in torsion. JOR; 36(8): 2266-2273, 2018.
29. Yang B, O’Connell GD. Swelling of fiber-reinforced soft tissues is affected by fiber orientation, fiber stiffness, and lamella structure. JBMMB. Jun; 82: 320-328, 2018. PMID: 29653381.
28. Ford AC, Chui WF, Zeng AY, Nandy A, Liebenberg MA, Carraro C, Kazakia G, Alliston T, O’Connell GD. A Modular Approach to Creating Large Engineered Cartilage Surfaces. J Biomech.; Jan.; 67: 177-183, 2018.
27. Bezci SE, O’Connell GD. Osmotic pressure alters time-dependent recovery behavior of the intervertebral disc. Spine. Mar 15;43(6):E334-E340, 2018.
26. Bezci SE, Klineberg EO, O’Connell GD. Effects of Axial Compression and Rotation Angle on Intervertebral Disc Mechanics in Torsion. J Mech Beh Biomed Materials. Jan.; 77:353-359, 2018.
2017
25. Yang B, O’Connell GD. Effect of collagen fiber orientation on intervertebral disc torsion mechanics. Biomech and Modeling in Mechanobiology. Dec.; 16(6): 2005-15, 2017.
24. O’Connell GD, Garcia J, Jamali A. 3D Bioprinting: New directions in articular cartilage tissue engineering.ACS Biomaterials Science & Engineering. 3(11); 2657-2668, Nov., 2017.
23. Werbner BN, Zhou M, O’Connell GD. A Novel Method for Repeatable Failure Testing of Annulus Fibrosus. J Biomech Eng. Nov. 1; 139(11), 2017.
2016
22. Stannard JT, Edamura K, Stoker A, O’Connell GD, Kuroki K, Hung CT, Choma TJ, Kuhns CA, Jefferies JT, Reinsel T, Cook, JL. Development of a Whole Organ Culture Model for Intervertebral Disc Disease. Journal of Translational Orthopaedics, April; 5:1-5, 2016.
21. Nover AB, Hou GY, Han Y, Wang S, O’Connell GD, Ateshian GA, Konofagou EE, Hung CT. High Intensity Focused Ultrasound as a Tool for Tissue Engineering: Application to Cartilage. Med Eng Phys, Feb; 38(2), 192-198, 2016.
2015
20. O’Connell GD, Leach JK, Kleinberg E. Tissue engineering a biological repair strategy for lumbar disc herniation. BioResearch, Nov 1;4(1):431-45. 2015.
19. Ponnurangam S, O’Connell GD, Hung CT, and Somasundaran P. Biocompatibility of Polysebacic Anhydride Microparticles with Chondrocytes in Engineered Cartilage. Colloids and Surfaces B: Biointerfaces, Dec 1;136:207-13, 2015.
18. Bezci SE, Nandy A, O’Connell GD. Effect of hydration on healthy intervertebral disc mechanical stiffness. Journal of Biomechanical Engineering, Oct 1; 137(10), 2015. Author copy.
17. O’Connell GD, Tan AR, Palmer G, Cui V, Bulinski JC, Cook JL, Attur M, Abramson SB, Ateshian GA, Hung CT. Human chondrocyte migration behavior to guide the development of engineered cartilage. Journal of Tissue Engineering and Regenerative Medicine, 2015.
16. Tan AR, Alegre-Aguaron E, O’Connell GD, VandenBerg CD, Aaron RK, Vunjak-Novakovic G, Bulinski JC, Ateshian GA, Hung CT. Passage-Dependent Relationship between Mesenchymal Stem Cell Mobilization and Chondrogenic Potential. Osteoarthritis and Cartilage, 23:319-327, 2015.
2014
15. O’Connell GD, Newman IB, Carapezza MA. Effect of long-term osmotic loading culture on matrix synthesis from intervertebral disc cells. BioResearch, Oct 1;3(5):242-9, 2014.
14. Ponnurangam S, O’Connell GD, Chernyshova I, Woods K, Somasundaran P, Hung CT. Ceria nanoparticles modulate development and interlukin response of chondrocyte-seeded hydrogel constructs. Tissue Engineering, Part A, Nov; 20(21-22):2908-19, 2014.
13. O’Connell GD, Nims R, Green J, Cigan A, Ateshian GA, Hung CT. Time and dose-dependent effects of chondroitnase ABC on growth of engineered cartilage. eCells and Materials Journal, Vol. 27: 312-320, 2014.
2013
12. Kelly TAN, Roach BL, Weidner ZD, Mackenzie-Smith CR, O’Connell GD, Lima EG, Stoker AM, Cook JL, Ateshian GA, Hung CT. Tissue-engineered articular cartilage exhibits tension-compression nonlinearity reminiscent of the native cartilage. Journal of Biomechanics, Jul 26; 46(11): 1748-91, 2013.
2012
11. O’Connell GD, Fong JV, Dunleavy N, Joff A, Ateshian GA, Hung CT. Trimethylamine N-Oxide found in shark cartilage improves collagen production in tissue-engineered cartilage. Journal of Orthopaedic Research, 30(12): 1898-905, 2012.
10. O’Connell GD, Lima EK, Bian L, Chahine NO, Albro MB, Cook JL Ateshian GA, Hung CT. Toward Engineering a Biological Joint Replacement. Invited review paper for the Journal of Knee Surgery; 25(3): 187-96, 2012.
2011
9. Sampat S*, O’Connell GD, Fong JV, Augaron EA, Ateshian GA, Hung CT. Growth Factor Priming of Synovium Derived Stem Cells for Cartilage Tissue Engineering. Tissue Engineering Part A, 17(17-18): 2259-65, 2011. *These authors contributed equally to the study and manuscript.
8. O’Connell GD, Sen S, Elliott DM. Human Annulus Fibrosus Material Properties from Biaxial Testing and Constitutive Modeling are Altered with Degeneration. BMMB, 11(3-4): 493-503, 2011.
7. O’Connell GD, Malhotra NR, Vresilovic EJ, Elliott DM. The Effect of Nucleotomy and the Dependence on Degeneration of Human Intervertebral Disc Strain in Axial Compression. Spine, 36(21): 1765-71, 2011.
6. O’Connell GD, Jacobs NT, Sen S, Vresilovic EJ, Elliott DM. Axial Creep Loading and Unloaded Recovery of the Human Intervertebral Disc and the Effect of Degeneration. Journal of Mechanical Behavior and Biomedical Materials, 4(7): 933-42, 2011.
5. O’Connell GD, Vresilovic EJ, Elliott DM. Human Intervertebral Disc Internal Strain in Compression: The Effect of Disc Region, Loading Position, and Degeneration. Journal of Orthopaedic Research, 29(4): 547-55, 2011.
2009
4. O’Connell GD, Guerin HL, Elliott DM. Theoretical and Uniaxial Experimental Evaluation of Human Annulus Fibrosus Degeneration. Journal of Biomechanical Engineering, 131(11): 111007, 2009.
2007
3. O’Connell GD, Johannessen W, Vresilovic EJ, Elliott, D.M. Human Internal Disc Strains in Axial Compression Measured Non-Invasively Using Magnetic Resonance Imaging. Spine 32(25), 2860-68, 2007.
2. O’Connell GD, Vresilovic EJ, Elliott DM. Comparison of Animals Used in Disc Research to Human Lumbar Disc Geometry. Spine 32(3), 328-33, 2007.
2006
1. Johannessen W, Cloyd JM, O’Connell GD, Vresilovic EJ, Elliott DM. Trans-Endplate Nucleotomy Increases Deformation and Creep Response in Axial Loading. Annals of Biomedical Engineering 34(4), 687-96, 2006.