March 31, 2018
Congrats to graduate student Bo Yang on having his paper titled “Swelling Behavior of Fiber-Reinforced Soft Tissues is Affected by Fiber Orientation, Fiber Stiffness, and Lamella Structure” accepted to the Journal of the Mechanical Behavior of Biomedical Materials.
Biological tissues are comprised largely of water. In the soft tissues of the musculoskeletal system, the ability to attract and imbibe water molecules is largely attributed to the glycosaminoglycan content in the tissue. This study looks at how tissue swelling behavior is altered with the addition of collagen fibers. Specifically, we evaluated fiber orientation, fiber network, and lamella structure (e.g., cross ply laminate structure). The findings are important for researchers developing new soft materials for biological or nonbiological applications.
March 19, 2018
Ongoing work by one of the Masters of Engineering Groups in the lab has been featured by the Fung Institute! Million Hands is a collaborative project with Alice Agogino and students are working on developing a low-cost framework to create functional finger prosthetics. Devices available on the market are largely limited to hand amputees, with limited options for people with congenital defects or finger amputations. Read more about their work here.
Feb. 12, 2018
Congratulations to Dr. Grace O’Connell on being selected as the 2017-2018 John Vaughan Scholar, which is distributed through the Arthritis National Research Foundation.
Feb. 8, 2018
Recent work in the lab focused on developing a microfluidic channel to assess 3D tissue growth potential of articular chondrocytes was highlighted this week on The National Arthritis Research Foundation Website. This work is in collaboration with Professor Lydia Sohn’s group in Mechanical Engineering.
Feb. 5, 2018
Congrats to Dr. O’Connell for receiving the prestigious NSF CAREER Award!
Jan. 31, 2018
Dr. O’Connell’s course “Designing for the Human Body” (ME178/ME278/BioE137/BioE237) was featured in the Mechanical Engineering Fall 2017 Mailer.
Jan. 25, 2018
Congrats to Semih Bezci on his paper titled “Contribution of facets, axial compression, and composition on human lumbar discs in torsion” being accepted for publication in the Journal of Orthopaedic Research.
This work is a continuation of Semih’s previous work studying torsion mechanics in bovine discs. In this paper, we evaluate the relationship between axial compression and axial rotation (torsion). The results of this study demonstrate that torsional mechanical properties of the disc are dynamic and increase with larger compressive loads. Or to think about it in another way, consider how much you can rotate your spine during yoga and compare that to rotating while carrying a heavy load in your hands. There will be more resistance to rotation with the heavier load.
Jan. 11, 2018
Congrats to Semih Bezci on passing his qualifying examination and advancing to PhD candidacy! Semih’s dissertation work will expand on his previous work that evaluated the role of tissue swelling in the intervertebral disc.
Dec. 23, 2017
Congrats to Ben Werbner and Minhao Zhou on their paper titled “A Novel Method for Repeatable Failure Testing of Annulus Fibrosus” being selected as an JBME Editors’ Choice Paper for 2017. You can find the article here.
Dec. 20, 2017
Congrats to Gabriel Lopez on being selected as a graduate student mentor for UC Berkeley’s SMART program (Student Mentoring And Research Teams). The program matches undergraduates and graduate students that will work closely performing research next summer.
Nov. 26, 2017
Congratulations to Minhao Zhou on receiving the Finnie Fellowship for the Spring 2018 semester! The fellowship will support Minhao’s research by funding his tuition and stipend for the semester.
Nov. 6, 2017
Dr. O’Connell’s upper level elective, ME C178/ BioE137: Designing for the Human Body was featured in the Fall UC Berkeley College of Engineering Magazine. The article discusses how design education has modified since Jacobs Hall opened in 2014.
Nov. 3, 2017
Congrats to Audrey Ford on her paper titled “A Modular Approach to Creating Large Engineered Cartilage Surfaces” being accepted for publication in the Journal of Biomechanics. Current tissue engineering strategies are limited in developing large-scale tissues with clinically-relevant dimensions. In Audrey’s work, she explored using the inherent stickiness of new tissue growth to develop larger tissue surfaces with dimensions that are relevant for clinical applications.
Sept. 15, 2017
Congrats to Semih Bezci on his paper titled “Effects of Axial Compression and Rotation Angle on Torsional Mechanical Properties of Bovine Caudal Discs” being accepted for publication in the Journal of the Mechanical Behavior of Biomedical Materials. In his work, Semih explores the relationship between rotation angle and axial compressive preload on torsional mechanics. The paper also provides statistical relationships between geometric parameters and mechanical properties, allowing researchers in spine biomechanics to easily account for differences in disc height or area and to compare results across various protocols presented in the literature.
Aug. 26, 2017
Congrats to Ben Werbner and Minhao Zhou on their paper titled “A Novel Method for Repeatable Failure Testing of Annulus Fibrosus” being accepted to the Journal of Biomechanical Engineering. Testing failure properties of fiber reinforced soft materials, such as the annulus fibrosus and meniscus, has been a significant challenge due to tissue specimens often failing prematurely at the grips. Ben and Minhao’s collaborative effort combined computational (finite element modeling) and experimental approaches to determine an appropriate geometry to ensure that tissue failure would occur in the mid-substance. Experimental tests validated our models with approximately 90% agreement.
Aug. 25, 2017
Congrats to Dr. O’Connell on being featured in this year’s Diablo Magazine 40 Under 40.
July 14, 2017
The O’Connell Lab has received a donation from a private donor and Berkeley alum for work with Professor Agogino on the Million Hands project. Part of this donation will also be used to expand ME178: Designing for the Human Body, which will focus on designing and prototyping prosthetics. A huge thank you from the entire lab!
July 13, 2017
Congratulations to Semih Bezci on having his paper accepted for publication in Spine. Passive diffusion is not sufficient for achieving full recovery from daily living; therefore, other mechanisms may play an important role in water absorption during an 8-hour bed-rest.
Semih’s recent research evaluated the role osmotic loading plays on time-dependent recovery behavior of the intervertebral disc following mechanical loading.
July 9, 2017
Recent work finite element modeling work by Bo Yang has been accepted for publication in Biomechanics and Modeling in Mechanobiology. In this study, Bo explores the importance of fiber angle orientation on disc mechanics in torsion, which will help researchers understand how some patients may be predisposed to more micro-damages in rotation or twisting. Read the author copy here.
July 6, 2017
Congratulations to Megan Pendleton for having her abstract accepted to the Annual ASBMR Meeting, which will be held in Denver, CO in September. Megan’s work focuses on understanding the effect of radiation on bone mechanical behavior. While her research is supported by NASA to understand what will happen to astronauts as they travel to Mars, her work can help cancer researchers understand what happens to noncancerous tissues following radiation treatment. You can find her abstract under Conference Proceedings.
June 28, 2017
The O’Connell lab welcomes two visiting students for the summer: Kai Littlejohn is an Amgen scholar from Tuskegee University and Carlos (Charlie) Osuna is visiting through the UC LEADS program from UC San Diego.
June 14, 2017
A new blog post by Dr. O’Connell on Stemation.com. Learn more about the award receipients of the 2017 Golden Gate Section Society of Women Engineeers (GGS SWE) Scholarship.
May 16, 2017
Congratulations to the class of 2017! The following students from the O’Connell Lab received their degree this week. We wish you the best of luck in your future endeavors!
Megan Pendleton, Mechanical Engineering
Nicole Cazares, Mechanical Engineering
Chun Err Chai, Mechanical Engineering
Shannon Emerzian, Mechanical Engineering
Haohan Gong, Bioengineering
Thomas Georgiou, Mechanical Engineering
Vyshalli Jagadeesan, Mechanical Engineering
Nupur Kaku, Bioengineering
Vishnu Koganti, Bioengineering
Michael Lee, Mechanical Engineering
Brooke Lohman, Bioengineering
Maya Mayson, Bioengineering
Viola Quach, Bioengineering
Jorge Ruiz, Mechanical Engineering
Jacob Ruprecht, Bioengineering
Taylor Shen, Bioengineering
Michael Singer, Mechanical Engineering
Minhao Zhao, Mechanical Engineering
Aran Bahl, Bioengineering
Anne Zeng, Bioengineering
Apr. 28, 2017
The O’Connell Lab has received funding from the Arthritis National Research Foundation to support a project in collaboration with Dr. Lydia Sohn of the Department of Mechanical Engineering. Their work aims to develop a low-cost high-throughput method for screening viable cell sources for cartilage tissue engineering.
Apr. 26, 2017
New article on the lab’s efforts in 3D bioprinting, which represents work spearheaded by Gabriel Lopez. Read the article here.
Apr. 2, 2017
Professor O’Connell accepted the 2017 PMSE (Polymeric Materials: Science and Engineering) Young Investigator’s Symposium at the 253rd American Chemical Society Meeting in San Francisco, CA.
Mar. 21, 2017
Congratulations to Bo Yang, Ben Werbner, and Minhao Zhou on having their abstracts accepted for presentation to the SB3C bioengineering conference. One of Yang’s abstracts on modeling soft tissue swelling was selected a finalist in the PhD competition! Read the abstract here.
Mar. 16, 2017
Dr. O’Connell presents the labs research on intervertebral disc mechanics with respect to injury and swelling to scientists at The Buck Institute for Research on Aging in Novato, CA.
Mar. 15, 2017
Drs. Alice Agogino and Grace O’Connell received the 2017 CITRIS Seed Funding Award to further develop low-cost hand prosthesis for children. The work will be performed in collaboration with Sanjay Joshi at UC Davis. CITRIS and the Banatao Institute is focused on supporting work that will create solutions for society’s most pressing challenges.
Mar. 10, 2017
Recent research from the O’Connell Lab is highlighted in this month’s UC Berkeley-UCSF Bioengineering Graduate Newsletter. Read the newsletter here!
Feb. 24, 2017
The 2017 ORS abstract titled “Herniation and Hydration Alters Quantitative MRI Parameters of the Intervertebral Disc” by Drs. Michael Wendland and Grace O’Connell was selected as a finalist for the Spine Section Member Poster Award. Read the abstract here.
Feb. 3, 2017
The lab goes bowling!
Feb. 2, 2017
Dr. O’Connell presents the labs research on intervertebral disc mechanics with respect to injury and swelling to scientists at the Lawrence Berkeley National Laboratory in Berkeley, CA.
Jan. 17, 2017
A new review paper by Dr. O’Connell and colleagues — Drs. Jeannette Garcia from IBM and Amir Jamali from orthopaedic surgery at UC Davis — has been accepted for publication to the ACS Biomaterials Science & Engineering Journal. The review article focuses on 3D bioprinting for articular cartilage repair. You can read the public access article here.